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For metabolism, HGH boosts a hormone called insulin-like growth factor-1 (IGF-1), which works like insulin to control your blood sugar levels

Your pancreas releases amylin alongside insulin after meals, and it plays a key role in telling your brain that you are full

The STEP 1 trial, published in the New England Journal of Medicine in 2021, showed that participants taking semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group

J Clin Endocrinol Metab 88(4):17721779

Pediatr Nephrol 41 , 277296 (2026)

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