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Building on this, Ward and colleagues also showed that mutation of other solvent-exposed amino acids surrounding I253 in mouse IgG1 could result in enhanced affinity at pH 6.0 towards a truncated soluble form of mouse FcRn as measured by surface plasmon resonance (SPR), resulting in increased serum persistence in WT mice [99]

Therefore, we estimate that program expenditures associated with the implementation of the provisions in this final rule, in combination with other policies associated with the statutory payment model and current policies we have adopted under the authority of section 1899(i)(3) of the Act, are expected to improve the quality and efficiency of items and services furnished under the Medicare program and would not be expected to increase program expenditures relative to those of the statutory payment model