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In terms of structure, several GLP-1RAs have been developed based on the naturally occurring protein exendin-4 (from the Gila monster, a lizard found in New Mexico and Arizona), which shares 53% homology with native (human) GLP-1 [49,50,51]

Preparation and functional evaluation of RGD-modified proteins as v3 integrin directed therapeutics

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Their incidence increases with dose but typically decreases over time as the body adapts to receptor activation