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This can be attributed to the absence of ZIP8 in enterocytes and bile canaliculi, reducing Mn absorption from the intestines and reabsorption from the bile, thereby indirectly leading to more Mn excretion

Current evidence has firmly established that intestinal dysbiosis represents a critical pathological component in the development and progression of DM (Yang et al., 2021)

10.1152/ajpgi.00064.2011 14 ChaboryE.DamonC.LenoirA.KauselmannG.KernH.ZevnikB.et al (2009)

Zepbound (tirzepatide for weight management / obesity): approved later (November 2023) based on robust phase 3 obesity trials (SURMOUNT) showing weight reduction vs placebo at 72 weeks

Be sure to review your full health history with your provider before starting and talk openly about side effects during treatment so you can get the support you need

Your provider will select the most appropriate formulation for your goals and health profile