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Barata P, Cooney M, Tyler A, Wright J, Dreicer R, Garcia JA

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[5] previously evaluated the separate roles of insulin and IGF-1 in directly regulating GH secretion, using the Cre/loxP system to knock down the insulin receptor (INSR) and IGF-1 receptor (IGFIR) in primary mouse pituitary cell cultures

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Gastrointestinal Issues: Nausea, vomiting, diarrhea, and constipation are common side effects, especially during the initial weeks of use