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Increased expression of the transcription factor krppel-like transcription factor4 (KLF4) promotes the expression of the E3 enzyme itchy E3 ubiquitin-protein ligase (ITCH).ITCH activates YAP by promoting the ubiquitination of the phosphatase large tumor suppressor 1 (LATS1).YAP can promote renal fibrosis after AKI by promoting the expression of transforming growth factor- (TGF-) and connective tissue growth factor (CTGF)[28]
There is increasing interest in developing tripeptides with targeted therapeutic functions, particularly for applications in wound healing 36 , 75 , 92 , as well as in cancer 60 , 170 , neurodegenerative 24 , 173 , and cardiovascular diseases 177 , 178 , and in the design of functional foods 179 , 182 , 188
Annu Rev Biochem 57(1):261283 Borg GAV (1982) Psychophysical bases of perceived exertion
Pernomian L, de Mello MM, Parente JM, Sanches-Lopes JM, Tanus-Santos JE, e Silva LT, Antunes-Rodrigues J, Dos Santos RD, Elias LL, Fabro AT, Silva CA
While the peptide might impact hormonal equilibrium and pathways related to ovulation and metabolic health, keep an eye on your hormones if you are considering it as part of a larger fertility protocol