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Every mile you logged, every interval you held, every set you finished your body consolidates all of it during deep, restorative sleep

The mammalian circadian timing system: organization and coordination of central and peripheral clocks

If you've been below therapeutic dosing or haven't adjusted lifestyle factors, extend the trial period while increasing your dose incrementally

If you have not yet reached the 8mg or 12mg maintenance dose, the solution is typically to continue escalation rather than making dietary changes

Vague claims of "feeling younger" are indistinguishable from a placebo

However, there are two conditions under which the NOS-independent pathway is known to be enhanced: low oxygen (hypoxia) (Zweier et al., 1995) and low pH (acidosis) (Jones et al., 2021