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Gently introduce the water, allowing it to run down the side of the vial, and then swirl gently until dissolved

14 LRP5/6 are coreceptors of Wnts and are located on the plasma membrane

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n=931) that demonstrated a statistically significant improvement in tear production favoring acoltremon over vehicle based on 10 mm increase in tear production at day 14 (treatment difference versus vehicle, COMET-2: 34.4%, COMET-3: 38.8%