Small molecules that trigger ferroptosis identified thus far include agents that inhibit GPX4 directly, molecules that deplete the GPX4 cofactor glutathione, and compounds that oxidize iron 1,9,11,12
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[24] [25] NAD+ depletion through disruption of mitochondrial homeostasis is a substantial contributor to the metabolic dysfunction in WS, according to a 2019 study
Using supplements as part of a stepped care approach can make sense for many people, though some clinicians recommend starting with medication when the risk from excess weight is high
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