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DOI:: 10.3390/biomedicines9081029 4.Barisic, Ivan

Options to evaluate for coronary artery disease: Invasive cardiac catheterization (preferred for patients at moderate/high risk of coronary artery disease)

This is followed by the release of nesfatin-1 which stimulates cholecystokinin secretion leading to a rise in bile salts from gallbladder emptying, and the binding of Takeda P protein coupled receptor 5 (TGR5) onto the surface of the enteroendocrine cells, all of which eventually culminates in GLP-1 secretion [9]

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Because of this multi-receptor mechanism, retatrutide has become an important compound in peptide research related to metabolic signaling and endocrine biology