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Monti and colleagues in Uruguay ran a double-blind crossover of 25 nmol/kg over four nights and found that although several sleep measures moved in the expected direction, none differed significantly from baseline or placebo, and where differences did reach significance for NREM and stage 2 sleep, the same differences already existed at baseline

However, recent studies, particularly those using Mendelian randomization, provide stronger evidence for a causal role, especially in certain cancers like breast cancer