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She thought the side effects werent worth the little weight she had lost, so she decided to go off the drug

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C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice

For these biological plausibility reasons, we utilized isoutofdomain to control the solution of the differential equations system to stay non-negative, so that the solver takes smaller time steps if the solution leaves the domain, unless the minimum step size is reached and integration is terminated