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The PI3K/Akt pathway plays a central role in mediating the body and survival effects of IGF1 LR3

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The pathogenesis of DN involves a variety of factors, such as altered haemodynamics, oxidative stress, and inflammation, and studies from animal models suggest that mitochondrial dysfunction plays an important role in the development of DN

It is important to note that the majority of this mechanistic research has been conducted in cell culture and animal models, with a significant proportion originating from a single research group

Soft tissue repair models