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From experiments with deletion of the hepatic expression of GCGR, it was concluded that -cell hyperplasia was probably due to a circulating factor (13)

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The internal solution for whole-cell and cell-attached recordings consisted of 126 mM K-gluconate, 10 mM NaCl, 1 mM MgCl 2 , 10 mM EGTA, 10 mM HEPES, 2 mM NaATP, and 0.1 mM Na 2 GTP, adjusted to pH 7.3 with KOH, with an osmolarity of 295300 mOsm

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