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Changes in the gut microbiome influence the hypoglycemic effect of metformin through the altered metabolism of branched-chain and nonessential amino acids

2021;54:e13134

The percentage of dead cells (SYTOX Green-positive cells) was calculated using Kaluza software

Wei J, Zhang Y, Dalbeth N, Terkeltaub R, Yang T, Wang Y, et al

Data analysis indicated significant differences in the metabolites between the Gly and negative control groups (Figure S1D, E), and the differences in amino acid and lipid metabolism were the most significant

Participants will examine how impaired glutathione synthesis and recycling contribute to oxidative damage, vascular dysfunction, and cardiometabolic imbalance, as well as how mitochondrial stress amplifies these effects