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DSB, SSS and BH edited the manuscript and made intellectual contributions

Age-related decline in gastric acid production and intrinsic factor availability may reduce the bodys ability to absorb oral B12 and other nutrients, making IM delivery a practical alternative

Although results may not be instant, improvements can be observed within a relatively short period

Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12) The improvement of the sleep-wake rhythm disorders appeared immediately after the administration of high doses (3,000 micrograms/day) of methylcobalamin