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GSM-directed therapy in peri/postmenopausal patients (or others with hypo-oestrogen states): NICE and UK resources support vaginal oestrogen as a local therapy for genitourinary symptoms of menopause, with patient counselling that systemic absorption is minimal and serious adverse effects are very rare

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The pens can continue to be stored in the refrigerator, maintaining the same temperature range of 36F to 46F (2C and 8C)

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