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Nat Med (2017) 23:8508

The rationale is elegant: because GLP-1 receptors are enriched in metabolically active brain regions, using GLP-1 as a delivery vehicle allows estrogen to be directed preferentially toward the central nervous system, potentially enhancing its neuroprotective effects while limiting systemic hormonal exposure

They shift us away from the medicate or operate model toward a more sophisticated understanding of how healing actually works

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Research Applications PT-141 continues to be studied as part of broader research into melanocortin receptor biology, peptide-receptor interactions, neuroendocrine signaling, vascular response, inflammation, and structure-activity relationships among synthetic peptide analogs

the oxygen and nitrogen atoms can accept hydrogen bonds from water and the N-H hydrogen atoms can donate H-bonds