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Rev Environ Contam Toxicol 173:137 Baumann PC, Harshbarger JC, Hartman KJ (1990) Relationship between liver tumors and age in brown bullhead populations from two Lake Erie tributaries

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This multimeric complex facilitates the autocatalytic activation of caspase-1, an inflammatory caspase, which cleaves pro-IL-1 and pro-IL-18 into their mature, biologically active forms, IL-1 and IL-18

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