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Cell-level pigment regulation In melanocytes, the MT-2 peptide activates the MITF transcription factor through the cAMP signaling pathway, promoting the expression of tyrosinase genes and increasing melanin synthesis efficiency by 4.8 times

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This gradient mechanismranging from low-concentration signaling blockade to high-concentration multi-pathway synergyexhibits concentration-dependent anti-inflammatory activity in LPS-stimulated HaCaT keratinocytes (1.520 M), with no cytotoxicity observed below 6 M (Nguyen et al., 2022)

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