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These data come from Cosmos, a dataset created in collaboration with a community of Epic health systems representing more than 277 million patient records from 1,500 hospitals and more than 36,000 clinics from all 50 states, Lebanon, and Saudi Arabia

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This integrated network explains the irreversibility of AKI-to-CKD transition: once the reciprocal amplification between ferroptosis, inflammation, hypoxia, and fibrosis is initiated, each component reinforces the others, driving progressive and persistent renal damage

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(2009) 90:814S21S