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The combination of surging demand and supply chain disruption led to months-long shortages in availability of tirzepatide (brand name Mounjaro approved for T2DM) and semaglutide (brand names Ozempic approved for T2DM and Wegovy approved for weight loss) (Fiercepharma, 2023

Therefore, various combination treatment options are being explored to maximize drug efficacy while minimizing side effects

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Is a 57 bpm Increase Clinically Significant

A direct thiol donor given IV when supplementation urgent (e.g., oxidant challenge / fulminant hepatic failure)