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The effects of citrulline supplementation on biomarkers associated with health outcomes have been previously investigated

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PMC 11112441

Nausea and Vomiting When it happens: Often worse when starting treatment and after increasing doses How to manage it: Eat smaller, more frequent meals

In contrast, glioma cell lines U87 and T98G show extreme intolerance to the combination therapy, evident from the significantly larger tail moment values, indicating substantial DNA damage caused by the combined use of metformin and simvastatin