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A relevant issue that remains controversial is whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on the pancreas or other extrahepatic tissues, or direct, i.e., through activating GLP-1R on hepatocytes

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Compounded semaglutidemanufactured in licensed 503A pharmaciescontains the same active pharmaceutical ingredient as branded versions but at lower cost and with greater dosing flexibility

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Notes: Food supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle