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By contrast, peptides such as PYY and apelin were discontinued primarily due to formulation limitations or tolerability at supraphysiologic dosespharmacologic rather than biological failuresand therefore meet criteria for re-evaluation

Another promising approach involves gold-coated iron oxide nanoparticles functionalized with folic acid for targeted delivery to cancer cells [116]

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Orozco L, Soler R, Morera C, Alberca M, Sanchez A, Garcia-Sancho J: Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study

The exact mechanisms are still being studied