p53 transcriptionally activates the expression of GLS2 (Jennis et al., 2016) and SAT1 (Ou et al., 2016) (a polyamine catabolic enzyme) and transcriptionally represses SLC7A11 (Jiang et al., 2015)
10.1016/j.taap.2004.12.016
However, its used to treat type 2 diabetes and may cause some weight loss as a side effect
Open questions How can we optimize the specificity of ROS-targeted agents for application across various cancer contexts, thereby improving precision in cancer treatment
Anand U, Yiangou Y, Akbar A, Quick T, MacQuillan A, Fox M, Sinisi M, Korchev YE, Jones B, Bloom SR, Anand P (2018) Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons
The additional peptide ensures adequate signaling across greater tissue volume