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The delayed release of Amarasate bitter extract in the upper duodenum stimulates the activation of TAS2R receptors on enteroendocrine cells to release GLP-1, CCK and PYY (appetite suppressing hormones)

Evdokimova V, Tognon CE, Benatar T, Yang W, Krutikov K, Pollak M, et al

Stacchiotti V, Rezzi S, Eggersdorfer M, Galli F

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Many patients report that appetite suppression gives them mental space to develop new eating patterns without the constant willpower drain of traditional dieting

Although, the lack of impact on exercise performance in this study may have been due to the lower dose of L-citrulline compared to other studies [15]