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The starting dose used in phase 2 clinical trials has been low, with a gradual, pre-specified dose-escalation schedule over subsequent weeks to improve tolerability

decisions are individualised based on procedure type, patient risk factors, and local hospital protocols

and, under accelerated approval, for noncirrhotic MASH with moderate to advanced liver fibrosis in adults

The 2.4 mg group lost the most weight, which means that among adults suffering from overweight or obesity and T2DM, SMG 2.4 mg once a week has achieved significant clinically significant weight loss (99)

This means the long chains of protein have been broken down into shorter chains of amino acids

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