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In the development of dulaglutide, alanine at position 8 in the native GLP-1 sequence was substituted with valine, and the peptide was fused to the Fc domain of immunoglobulin G to confer resistance to DPP-4 degradation

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It performs an array of critical functions, including detoxifying drugs, protecting macromolecules from oxidative damage, and maintaining immune functions [ 1]

Take the simultaneous inhibition of apoptosis and ferroptosis as an example: in cellular model experiments, co-administration of an apoptosis inhibitor (such as the Caspase inhibitor Emricasan) and a ferroptosis inhibitor (such as Ferrostatin-1) significantly increased neuronal survival, far exceeding the effects of using either inhibitor alone [311]