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The documented mechanisms are: VEGF stimulation in dermal fibroblasts that supports the microvascular network feeding the follicle, collagen and glycosaminoglycan synthesis at the follicular basement membrane, anti-inflammatory signaling that calms the chronic micro-inflammation associated with androgenetic alopecia, and direct follicular signaling that extends the anagen growth phase

* Correspondence: Lu Zhang, [email protected]

Freezing will not sterilize a contaminated solution

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Animal experiments have produced intriguing findings

In our experimental design, we established a D-galactose-induced aging mouse model and injected the experimental group mice with FOXO4-DRI for 1 month, while the control group was injected with equal amounts of PBS