Dietary Limitations: Many "fad" diets focus on extreme calorie reduction, which can slow metabolism over time and lead to nutrient deficiencies
[DOI] [PubMed] [Google Scholar] 33.Carvalho M, Remio F, Milhazes N, Borges F, Fernandes E, Monteiro Mdo C, Gonalves MJ, Seabra V, Amado F, Carvalho F, Bastos ML
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Clin Cancer Res (2015) 21:74955
This combinatorial approach may ultimately prove more flexible than the all-in-one triple-agonist strategy, because it allows each component to be dosed independently and titrated to individual response
These therapies aim to enhance WL and improve metabolic outcomes by engaging multiple hormonal pathways, with preclinical and early-phase clinical trials supporting their potential as next-generation obesity treatments [16,17,18,19,20,21,22,23]