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Patients with a personal or family history of breast cancer should use choline supplementation cautiously, as some observational studies suggest high-dose choline intake correlates with increased breast cancer risk in genetically susceptible populations

doi: 10.1038/s41422-020-00441-1

The strengths of this meta-analysis are the inclusion of all GLP-1RA CVOTs published until June 2021, the very large number of participants, the use of MACE as the main endpoint, the high quality of all trials which minimizes the risk of bias, and the absence of heterogeneity for all the endpoints considered

The protocol from Celsis for assessing microsomal- dependent drug metabolism was followed with minor adaptations