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And the uncomfortable question at the center of it all became impossible to ignore: who should pay for the most popular class of drugs in modern medicine

Absence of evidence is not proof of failure

J Am Med Assoc

There is biological plausibility for pancreatic complications due to the supraphysiological stimulation of the pancreas, leading to hyperplasia

If symptoms persist beyond the early titration period, temporary dose stabilization or dose reduction should be considered