Their cardiovascular value evident in clinical trials has also expanded their usage in cardiovascular morbidity
Future research should prioritize adequately powered randomized controlled trials evaluating combined SGLT2 inhibitor and GLP-1 receptor agonist therapy in patients with HF
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist
A significant reduction in RR was observed in the primary outcomes, such as cardiovascular death or worsening of HF, compared with placebo in the overall population (RR 0.82, 95% CI 0.73 to 0.92)
For a highdemand therapy like Wegovy, that means considering: Longterm cost trends, not just short-term uptake Whether alternatives offer similar outcomes at lower cost Employers want predictable costs
Glucagon-like peptide (GLP) type 1 was subsequently identified as another active incretin [4]