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Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-1

The Phase IIb clinical trials failed because AOD 9604 did not produce a statistically significant amount of weight loss in obese patients compared to a placebo

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Replacement of osteogenic cells with BMAT decreases bone quality and contributes to an overall poor metabolic environment

Q J Med 1972;41:437e56

Expression and function of 3beta hydroxisteroid dehydrogenase (3beta HSD) type II and corticosteroid binding globulin (CBG) in granulosa cells from ovaries of women with and without endometriosis