Collectively, these observations demonstrate that macrophages exhibit distinct expression profiles and associated functional activities that are highly specialized in response to the islet microenvironment
Microglia and infiltrating monocyte-derived macrophages are the predominant innate cells in active lesions, where they accumulate in large numbers and contain abundant myelin debris, reflecting their central role in demyelination (122)
These effects were mediated through enhanced AMP-activated protein kinase signaling and diminished PI3K/Akt signaling, indicating that glutamine supports intestinal barrier function via modulation of specific intracellular pathways (110, 118)
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