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doi: 10.1038/s41591-018-0104-9 18 OseiniAMSanyalAJ

Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers

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Animals were housed at 24 2 C, 55 15% humidity, under a 12 h light/dark cycle, with ad libitum access to water and standard chow

No cases of pancreatitis, thyroid C-cell tumours, or severe hypoglycaemia were reported in the Phase 2 cohort

The phase 1b, 16-week, multiple-dose ascending trial (NCT05613387) showed a mean body weight reduction of 4.8%, 8.6% and 8.3% at OW doses of up to 2.4 mg, 4.8 mg and 9.0 mg, respectively [116]