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The mechanisms underlying these CV benefits include promoting myocardial glucose uptake and utilization, reducing oxidative stress, inhibiting cardiomyocyte apoptosis, vasodilation, improving coronary blood flow, natriuresis, anti-inflammatory effects, renal protection, reducing plaque formation, and neurohormonal regulation (22)

The polar and charged residues lining the enzymes binding pocket likely contribute to the formation of an electrostatic environment essential for substrate interaction ( 115 inactivates CHAC1, preventing GSH depletion in vivo ( The molecular mechanism of -glutamyl amino acid degradation by GCT family enzymes is well understood

& Rothman, S

5-Amino-1MQ is a synthetic small molecule designed forin vitro laboratory researchandnon-human studies

Lee SC, Miller S, Hyland C et al

Clinicians should watch for it in the first few months after starting a patient on a GLP-1.For people prone to alcohol- or triglyceride-induced pancreatitis, GLP-1 drugs may actually reduce those risks.Bottom line: the answer to "do GLP-1s cause pancreatitis?" depends on the cause of pancreatitis.Paper led by Yan Xie @Biostayan and Taeyoung Choi