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Both drugs help improve insulin sensitivity while decreasing insulin resistance

The Aib substitution introduces a gem-dimethyl group on the alpha-carbon, creating steric hindrance that prevents DPP-4 from accessing the scissile bond

It can feel annoying, but most people find it can be controlled and doesnt last too long

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The GLP-1 sequence is highly conserved between the species, with no sequence variation occurring in mammals

However, the health benefits are often even more significant for older individuals because they are at higher baseline risk for obesity-related diseases