-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia
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doi: 10.21037/atm-22-6390 63 KuroyanagiGAdapalaNSYamaguchiRKamiyaNDengZAruwajoyeOet al
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AOD-9604, also known as Anti-Obesity Drug-9604, is a synthetic analog of the human growth hormone developed by Metabolic Pharmaceuticals
Albiston AL, Diwakaria S, Fernando RN, Mountford SJ, Yeatman H, et al