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The largest arm of ibutamoren containing an indoline-3,4-piperidine ring structure forms hydrophobic and cation- interactions with the side chains of GHSR residues F286 6.58 and R102 2.63 , respectively

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This exchange mechanism imports cystine in exchange for glutamate, and once inside the cell, cystine is reduced to cysteine, a rate-limiting precursor for glutathione (GSH) synthesis