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It does mean the question is finally being tested in a way that can generate more useful human data

(5) M V Graf, A J Kastin, D H Coy, and A J Fischman (1985) Delta-sleep-inducing peptide reduces CRF-induced corticosterone release Neuroendocrinology, 1985 Oct, Volume 41 (Issue 4), Pages 353-6

Craving and Stress Support Chronic stress can increase the production of cortisol by the adrenal glands, a hormone that helps the body respond to stress, but when chronically elevated can lead to adverse changes in mood, sleep, and eating habits