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In addition to regulating cardiomyocyte function, GLP-1RAs also improve the function of cardiac fibroblasts

The addition of large anionic groups (such as GSH) detoxifies reactive electrophiles and produces more polar metabolites that cannot diffuse across membranes, and may, therefore, be actively transported

10.1016/j.cell.2006.09.024 Cell 451 StrongM

The preclinical data does not support a linear dose-response curve for efficacy

The culmination of all of these studies come to light with the finding of several (some reported and many from our group still publication pending) Larons Syndrome (congenital IGF-1 deficiency or GH insensitivity) never treated patients who underwent progression to MetS and ultimately to T2D together with diabetic retinopathy when they reached their late 30 s, [250, 251]

10.1073/pnas.0501814102 P