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Tri-State Neurosurgical Associates-UPMC Administrative Oakland Office Address: Presbyterian University Hospital Department of Neurosurgery Suite 5C 200 Lothrop Street Pittsburgh, PA 15213 Phone: 1-888-234-4357 2013 Tri-State Neurosurgical Associates UPMC

Regarding the catalytically advantageous nature of Sec, studies of Cys-substituted murine GPx-1 indicate that in the context of mammalian Sec-containing GPxs, the Sec active site may have the added advantage of being less sensitive to overoxidation and inactivation in the presence of peroxides compared to Cys (309)

Agonist Development of agonistic analogs of GH-RH The first synthetic analog we developed, [Nle27] GH-RH (129) NH2, replacing Met27 with norleucine (Nle), effectively stimulated GH secretion via intravenous and subcutaneous administration 63,64

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Samms RJ, Coghlan MP, Sloop KW