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Brain MRI in individuals with Wilson disease (Figure) commonly reveals changes on T1- or T2-weighted sequences within the bilateral basal ganglia as well as the thalami and brainstem

P01AG049665 to N.S.C

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Poor predictive performance was considered to be a consequence of a number of factors such as reliance on a single model, the development phase/stage of ToxCast, the cytotoxicity scoring and correction system, the weighting approaches and chemical selection utilised (174)