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Am J Pathol (2005) 166(2):43342.10.1016/S0002-9440(10)62266-3 70 TariqMMasoudMSMehmoodAKhanSNRiazuddinS

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In a mouse model of AKI-CKD transformation induced by nephrotoxic substances aristolochic acid (AA) and folic acid (FA) and the HK-2 cells treated with AA, the increased expression of HDAC3 leads to the downregulation of GPX4 mRNA, thereby promoting the progression from AKI to CKD

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The blend ratio is usually 1:1, meaning equal milligram amounts of each peptide, though some formulations offer 2:1 or custom ratios depending on research objectives