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L-Glutathione lightens the skin while Kojic acid helps to even out skin tone and reduce the appearance of blemishes and dark spots

Meanwhile, mitochondrial damage mediated by PCD protein 2 can increase the generation of mitochondrial reactive oxygen species, synergistically inducing autophagy and ferroptosis [113]

Guo Y, Wang M, Zou Y, Jin L, Zhao Z, Liu Q et al (2022) Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer

No evidence package for common commercial routes FDAs briefing found no adequate human studies for the commonly proposed oral, subcutaneous, nasal, or transdermal routes

Aspirin Given as an intraperitoneal or as an intragastric challenge, aspirin disturbed both lower esophageal sphincter and pyloric sphincter, but the effect appears to be relatively mild