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Therefore, E4-related bioenergetic dysfunction, such as impairments in FAO of the cerebrovasculature, could have detrimental impacts on its transport functions

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SA node effect shud be right from beginning, why sympathetic effect on SA shows after a lag at 24 weeks, also if it's as shown in graph peaks after hiatus is this due to drug induced Increased basal metabolic rate(obvioous will be increased HR)

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