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Further in vitro studies have shown that IAA can promote epithelial cell proliferation and enhance tight junction repair by activating the AhR/IL-22 signaling pathway, thereby counteracting LPS-induced epithelial injury and preventing LPS-driven systemic inflammation 168

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5 Limitations and safety concerns in conventional oral and topical delivery of flavonoids 5.1 Pharmacokinetic limitations to the oral bioavailability of flavonoids Flavonoids exhibit broad pharmacological activities, particularly in dermatological disorders

Disturbance in glutathione homeostasis has also been related to the etiology of a range of other diseases including cardiovascular, cancer, diabetes, cystic fibrosis, ageing, and illnesses related to excess oxidative stress [13,14,15,16,17]