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Furthermore, nuclear factor erythroid-2-related factor 2 (Nrf2), a key transcriptional regulator of both GSH biosynthesis and GPX4 expression, is garnering increasing attention

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The induction was observed also in plants harboring a tetramer of the ocs element from the GSTF8 promoter, suggesting that this element helps to mediate the response (Perl-Treves et al., 2004)

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Free fatty acid oxidation generates reactive oxygen species faster than endogenous antioxidant systems can neutralise them